Hemoperitoneum After Cyst Rupture Under Warfarin Treatment In Young Women

Warfarin is a coumarin anti-coagulant, widely used for the therapeutic and prophylactic anti-coagulation. In young women can be administered as a therapy after deep vein thrombosis and can increase the adverse event of bleeding in case of a corpus luteum cyst rupture. We present two cases of young women who presented with pain, anaemia, tachycardia and fluid inside the peritoneal cavity to the emergency unit, which were treated with warfarin and had increased level of INR. Laparoscopy was the procedure of choice after an intensive therapy for lower the INR. The course of the patients was uneventful with discharge after third, respectively fifth day. In young women which are under therapy with warfarin any sudden abdominal pain might be a sign of a hemoperitoneum, which can be treated usually laparoscopic; the timing of the surgical procedure is dictated by the INR and the grade of the haemorrhagic shock.