Segmented Ivf - A Modern Method Of Optimizing Results In Assisted Reproduction

IntroductionWith the improvement of cryopreservation techniques, the freezing of the embryo surplus has become a common practice in assisted reproduction. Segmenting the in vitro fertilization (IVF) cycle through the alternative use of GnRH agonists for the induction of final follicular maturation accompanied by the so called 'freeze-all' practically eliminates the severe ovarian hyperstimulation syndrome (OHSS). There is also a widespread opinion that this strategy brings additional benefits in terms of success rates, considering that the supraphysiological levels of steroids from the stimulated cycle have a negative influence on endometrial receptivity.Material and methodWe conducted a retrospective study on the IVF cycles at the Ominiclinic Fertility Center in Iasi from January 2017 to December 2017, following the success rate of the embryo transfer procedures on the stimulated cycle and of those with cryopreserved embryos.Results101 fresh transfers in 88 couples and 145 frozen-thawed embryo transfers in 96 couples were performed during the study period. The pregnancy rates were similar in the two groups. There were no cases of severe OHSS.ConclusionsSegmenting IVF cycles can be beneficial in many situations, both in terms of success rates and reduced morbidity associated with assisted reproduction. The best ways to prepare the endometrium for embryo transfer are still under study.