Nafld (Non-Alcoholic-Fatty-Liver-Disease) Reversal By A Comprehensive Nutritional-Physical Exercise Intervention.

Introduction NAFLD is a condition detrimental for the liver, subsequent to unhealthy lifestyle. We aimed to study relationship of nutritional and exercise intervention with improvement or recovery of UltraSound (US) fatty liver pattern Methods Fatty liver was assessed by a US validated procedures,Bright Liver Score (BLS), in 169 (F 197,M 62) patients,aged 48.51 ± 16.17 years, BMI 27.45±5.23. A counseling intervention (6 months) aimed at increasing adherence to Mediterranean Diet profile (AMDS; range 0–55), assumed as a qualitative proxy for current dietary guidelines, and at reducing sedentary habits assessed by detailed physical activity(Baecke)was provided. Results Post‐intervention changes were: BLS (from 1.07±1.08 to 0.80±0.89; p< 0.0001)and insulin resistance (HOMA from 2.47±1.42 to 1.95 ±1.14;p< 0.0001) decrease; increase of AMDS (from 29.48±4.61 to 31.95±3.51; p<0.0001) and Baecke‐Physical activity score(from 41.50±4.97 to 43.97±4.95; p<0.0001). AMDS change has a significant correlation with weight loss (r= 0.406; p<0.0001),BLS decrease( r=0.420; p<0.0001), and Baecke increase ( r=0.252; p:0.015); not with HOMA changes (r= 0.099; p: 0.346). This outcome was maintained after 24 months in 92 re‐assessed patients. Conclusion Increased adherence to Mediterranean Diet profile and to a greater physical exercise activity concurs and improves liver in NAFLD patients.