Interleukin-16 Gene Polymorphism Is Associated With Acute Coronary Syndrome In The Chinese Han Population

Acute coronary syndrome (ACS) is clinical syndromes caused by coronary atherosclerosis plaque rupture or attack, which can lead to complete or incomplete pathological basis of occlusive thrombosis. Evidences have indicated the importance of gene polymorphism in the pathological progression of coronary heart disease risk. The purpose of this study was to investigate the associations between polymorphisms in interleukin-16 (IL-16) single nucleotide polymorphisms (SNP) and the risk of ACS in Chinese Han population. A total of 238 patients and 178 healthy individuals were recruited in this retrospective cohort. Genotyping of IL-16 rs8034928, rs3848180, rs1131445, rs4778889 and rs11556218 SNPs was performed by PCR-restriction fragment length polymorphisms. Results showed that the G allele in rs3848180 and C allele in rs1131445 were higher frequencies in ACS group than healthy group. We found that G/G genotype in rs1131445 showed a significant higher risk of CAS (OR=1.28, 95% CI=0.94-2.55). Variant of rs3848180 presented a significant increased risk of CAS in dominant (OR=1.44, 95% CI=1.04 -2.68). The allele C demonstrated a significant risk of CAS (OR=1.26, 95% CI=1.12-2.08) and T/T in rs3848180 were found to be associated with increasing risk of CAS (OR=1.66, 95% CI=1.07-4.25). In conclusion, these results showed that rs1131445 and rs3848180, SNPs of IL-16 are associated with CAS risk in Chinese Han population, which provide the possibility of statistical power calculation to predict the susceptibility of ACS.