The Gastric Bypass Combined Ileal Transposition Having A More Significant Effect In Improving Glucose Tolerance And Islet Sensitivity Than Gastric Bypass On Type 2 Diabetes

Aims: To compare the GBP with IT and only GBP in nonobese type 2 diabetes. Methods: Goto-Kakizaki (GK) rats were used to construct the T2DM animal models. Gastric bypass and joint ileal transposition surgery gastric bypass were done in the two groups. Weight, fasting blood glucose, insulin, C-peptide, IAI, FBCI and the islet beta cell of rats were detected and compared between two groups. SPSS 16.0 statistical software was employed for statistics. There was statistically significant difference when P<0.05. Results: Postoperative fasting blood glucose, postsurgical glucose tolerance of rats were significantly lower than preoperative in both groups (P<0.01). And postoperative insulin level of rats significantly increased than preoperative (P<0.01) in both groups. Rats' postoperative C-peptide, insulin sensitivity levels increased significantly than preoperative (P<0.01) in both groups. GBP + IT was more significant than the effect of GBP in improving glucose tolerance and enhanced insulin sensitivity persistence. Conclusion: Both GBP and GBP + IT could significantly make a significant treatment effect on type 2 diabetes, while GBP + IT had a more significant effect in improving glucose tolerance and islet sensitivity which could improve persistence.