Synthesis Of 2-Chloro-N, N-Diethyl-7-Fluoroquinazolin-4-Amine
2018 4TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION(2019)
Abstract
7-fluoroquinazoline-2, 4-diol is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from 2-amino-4-fluoro benzoic acid and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 51%.
MoreTranslated text
Key words
synthesis,n-diethyl
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined