Ethyl 6-Methyl-2-Oxo-4-{4-[(1-Phenyl-1h-1,2,3-Triazol-4-Yl)Methoxy]Phenyl}-1,2 ,3,4-Tetrahydropyrimidine-5-Carboxylate

The Biginelli reaction is an acid-catalyzed, three-component reaction between an aldehyde, a hydrogen methylene active compound, and urea (or its analogue) and constitutes a rapid and easy synthesis of highly functionalized heterocycles. Synthesis of ethyl 6-methyl-2-oxo-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylate, identified by our laboratory code LaSOM 293, was achieved using the Biginelli reaction as the key step, followed by the Huisgen 1,3-dipolar cycloaddition in a convergent four-step route. The product LaSOM 293 was obtained with a yield of 84%.