Effect Of Different Depth Of Anesthesia On Postoperative Cognitive Function After Retroperitoneal Laparoscopic Radical Nephrectomy

Postoperative cognitive function could be influenced by different depth of anesthesia and different types of abdominal surgery. Laparoscopic partial nephrectomy has become widely used for surgical method of renal cell carcinoma (RCC) in the past few years, and it also led central nervous system complications as well. The objective of the present study was to investigate the effects of different depths of sedation on postoperative cognitive function in patients undergoing retroperitoneal laparoscopic radical nephrectomy. A total of 100 patients undergoing retroperitoneal laparoscopic radical nephrectomy were randomly divided into 3 groups. Anesthesia with the usage of propofol and remifentanil, which was adjusted to maintain bispectral index (BIS) at 30 < BIS <= 40 with 32 patients in group I, 40 < BIS <= 50 with 35 patients in group II, and 50 < BIS <= 60 with 33 patients in group III. Mini-Mental State Examination (MMSE), Trail-Making Test (TMT) and Clock Drawing Test (CDT) were used to evaluate the cognitive function one day before and after surgery. We found that no significant statistical difference was found in demographic data among patients in the 3 groups (P > 0.05). MMSE score in group I was significantly higher than the other 2 groups post-operation (P < 0.05). Meanwhile, TMT completion time in group I was also found to have markedly lower than the other 2 groups (P < 0.05). Besides, CDT score in group I and group II were significantly higher than that in group III, and no significant difference was found between group I and group II. Thus, we come to a conclusion that 30 < BIS value <= 40 had the minimal influence on postoperative cognitive function after retro-peritoneal laparoscopic radical nephrectomy.