Correlation Between Hpv Infection And Tumor Recurrence In Patients With Head And Neck Squmaous Cell Carcinoma In Tangshan, China

To explore the HPV infection status in head and neck carcinoma tissues, clinical features of HPV positive patients and its correlation with tumor recurrence in Tangshan area, China. In total, 418 cases of head and neck carcinoma specimens were selected from January 1, 2003 to December 31, 2013 in Tangshan Union Hospital. PCR-reverse dot blot hybridization was used to detect HPV DNA. The clinical pathological features of HPV positive patients with head and neck cancer and its relationship with tumor recurrence were analyzed. Results showed that the detection rate of HPV in head and neck carcinoma tissues was 20.8% (87/418) in the Tangshan area. Most common subtype was HPV16, and a few were HPV11, HPV35 or HPV58. Among them, the detection rates in the carcinoma tissues of larynx, oral, hypopharynx and oropharynx were 19% (19/100), 29.3% (24/82), 26.1% (12/46) and 28.6% (32/112), respectively. There was no HPV detected in the adenoid cystic carcinoma of salivary glands (0/78). There were significant differences in HPV detection rates between different tumor tissues (P<0.05). The HPV detection rate in the smoking group was 13.1%, which was lower than that of the non smoking group (33.3%), and the difference was statistically significant (P<0.05). The HPV detection rate in the recurrent group was 3.9%, lower than that in the non-recurrence group (30.7%), and the difference was statistically significant (P<0.05). There was no significant correlation between HPV detection rate and gender, age, classification and staging of the patients (P>0.05). Multivariate logistic regression analysis showed that tumor differentiation (R = 1.549, 95% CI = 1.131 similar to 2.122) and HPV infection (OR = 0.089, 95% CI = 0.038 similar to 0.210) were the main factors affecting the recurrence (P<0.01). Our findings support that the detection rate of HPV is low in the head and neck carcinoma tissues in the Tangshan area. HPV positive patients are mostly non smokers. The head and neck carcinoma patients with poor differentiation and HPV negative status have a high recurrence rate. Routine HPV detection is necessary for patients with head and neck cancer in order to warn of early tumor recurrence.