Chronic Eosinophilic Leukemia Initially Presenting With Psychotic Symptoms: One Case Report And Literature Review

Chronic eosinophilic leukemia (CEL) is a myeloid malignant proliferative disease with autonomous and clonal proliferation of eosinophilic precursor cells, leading to a persistent increase of eosinophils in the peripheral blood, bone marrow, and surrounding tissues. Along with in-depth research on the pathogenesis and targeted drugs of CEL, imatinib mesylate has been applied in treating CEL. Signs and symptoms of CEL primarily consist of weight loss, cough, fever, malaise, skin and mucosal lesions and diarrhea, etc. Nevertheless, CEL patients presenting with psychotic symptoms as the main manifestations have not been reported. In this article, one case of CEL was manifested with psychotic symptoms. The male patient, 55 years old, was admitted to our hospital due to restlessness and agitation for 3 weeks and increased white blood cell count for 2 weeks. The special clinical manifestations, clinical diagnosis, and treatment process of this patient are summarized, aiming to provide clinical evidence for the diagnosis and therapy of CEL for relevant clinicians.