Thrombin Induces Expression Of Sphingosine Kinase-1 (Sphk-1) In Human Vascular Smooth Muscle Cells Via The Mrna Stabilising Protein Hur. Inhibition By Dabigatran Reduces Vascular Sphk-1 Expression And Atherosclerotic Burden In Vivo

Swen Ermler,Andreas Boehm,Anke C. Rosenkranz,Karsten Schroer,Bernhard H. Rauch

CIRCULATION（2011）

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摘要

Objective: Sphingosine-1-phosphate (S1P) is a cellular signaling lipid generated by sphingosine kinase-1 (SPHK-1). This study investigated the potential regulation of SPHK-1 in thrombin-stimulated ...

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关键词

Thrombin, Dabigatran, Arteriosclerosis, Smooth muscle, Plaque

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