Formulation And Evaluation Of Oral Disintegration Tablets Of Omeprazole

Omeprazole fast disintegrating tablets were prepared by using different superdisintegrants like crospovidone, croscarmellose sodium and Sodium starch glycolate by direct compression. Precompression parameters were conducted for all formulations blend and were found to be satisfactory. The prepared tablets were evaluated for various parameters like content uniformity, hardness, friability, wetting time, water absorption ratio, disintegration time and In-vitro dissolution. The results indicated that the tablets complied with the official specifications. The disintegration studies shown that the all formulations disintegrated in less than 1 minute. The formulation F3 shown less disintegration time of 15 seconds. The croscarmellose sodium and sodium starch glycolate shown more disintegration time than crospovidone. In the present study, three Superdisintegrants representing each of the three main classes of superdisintegrants differed in their ability to disintegrate model tablet into their primary particles when used at the same w/w percentage concentration.