N-(4-Bromobenzyl)-2-(5,6-Dimethyl-1h-Benzo[D]Imidazol-2-Yl)Benzeneamine

MOLBANK(2018)

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Abstract
N-(4-Bromobenzyl)-2-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)benzeneamine was obtained by condensation of N-(4-bromobenzyl)-3,1-benzoxazine-2,4-dione (N-(4-bromobenzyl)isatoic anhydride) with 4,5-dimethyl-1,2-phenylenediamine in refluxing acetic acid. This is a rare example of condensation of N-substituted 3,1-benzoxazine-2,4-dione with 1,2-phenylenediamine, which resulted in the formation of a benzimidazole derivative with a moderate yield. Crystallographic studies and initial biological screening were performed for the obtained product.
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Key words
substituted benzimidazoles, 3,1-benzoxazine-2,4-dione, isatoic anhydride, 1,2-phenylenediamine, crystallographic studies, cytotoxicity
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