Reduced Expression Of Mir-506 In Glioma Is Associated With Advanced Tumor Progression And Unfavorable Prognosis

Background: MicroRNAs regulate gene expression at the post-transcriptional level and play important roles in cancer progression. The aim of this study was to investigate the expression level of miR-506 as well as its association with glioma progression and prognosis. Methods: miR-506 expression in glioma tissues and normal brain tissues was measured by quantitative real-time PCR (qRT-PCR). Survival curves were plotted using the Kaplan-Meier method and differences in survival rates were analyzed using the log-rank test. Results: Our data showed that miR-506 expression was down-regulated in glioma tissues compared with normal brain tissues (P<0.05). The low miR-506 expression was found to be correlated with advanced WHO grade and low Karnofsky performance score (KPS) of glioma patients (P<0.05). In addition, the overall survival of patients with low miR-506 expression was shorter than those with high miR-506 expression (P<0.05). Furthermore, multivariate analysis suggested that miR-506 expression was an independent prognostic factor for glioma patients. Conclusion: These results indicated that miR-506 expression was decreased in human glioma and associated with tumor progression and prognosis of patients, indicating that miR-506 might be involved in glioma carcinogenesis and become a potential prognostic biomarkers for glioma.