A Preliminary Comparison Of Clinical Efficacy Between Laparoscopic And Open Surgery For The Treatment Of Colorectal Cancer

Objective: To explore the clinical efficacy and safety of laparoscopic and open surgery for colorectal cancer. Methods: From May 2011 to May 2012, 227 patients pathologically confirmed as colorectal cancer in our hospital were divided into laparoscopic surgery (LS) group (n=152) and open surgery (OS) group) (n=75) according to the total mesorectal excision (TME) principle. Clinical data including postoperative complication rate and long-term efficacy were observed and compared between two groups. Results: All the patients completed the surgery, and no mortality was found during the perioperative period. No patient in LS group needs laparotomy. The duration of LS was significantly longer than that of the OS group, the difference was statistically significant (P<0.05); blood loss in LS group was significantly less than that in the OS group (P<0.05); the anus preservation rate and the number of lymph node in LS group and OS group showed no significant difference (P>0.05). The mean time to passing first flatus and oral intake for solid foods in LS group were earlier than those in OS group, while the laparoscopic group indwelling time of a urethral catheter and the length of hospital stay were shorter than those in OS group (P<0.05). The incidence of infection in LS group was 5.3% (8/152), which was significantly lower than that in the OS group 22.7% (17/75) (P<0.05). No statistically significant difference was found among one-year (98.7% vs 97.3%), two-year (90.1% vs 92.0%) and three-year (77.6% vs 80.0%) survival rate (P>0.05). No statistically significant difference was found in 3-year local recurrence rate (2.0% vs 1.3%) and metastasis rate (9.2% vs 10.7%) between the two groups (P>0.05). Conclusions: Laparoscopic surgery for treatment of colorectal cancer is feasible and the short-term and the long-term therapeutic efficacy is similar to that of open surgery. However, Laparoscopic surgery has advantages in postoperative recovery, infection rate and length of postoperative hospital stay.