Significance Of T Lymphocyte In The Serum Of Cytomegalovirus-Induced Hepatitis

The aims was to investigate the influence of cytomegalovirus infection on the expression of T lymphocyte. 70 children with cytomegalovirus-induced hepatitis were enrolled in this study. According to the different viral loads, children were divided into high viral load group (n=16), medium viral load group (n=31) and low viral load group (n=23), meanwhile, 40 healthy children were as control group enrolled in this study. Furthermore, the expression of T-lymphocyte subsets in peripheral blood were observed and Spearman method was used to analyze the relationship between the expression of T-lymphocyte subsets and cytomegalovirus load. Compared with control group, the total amount of T lymphocytes were fewer and results showed that the numbers of CD4+ T cells and the ratio of CD4 and CD8 reduced. Moreover, in different subgroups, the numbers of T cells were more in medium viral load group than that in high viral load group, and both groups were fewer than low viral load group, which was significant difference (P<0.05). Additionally, Spearman analysis showed that the cytomegalovirus load was negative correlation with CD3, CD4 numbers and the ratio of CD4/CD8. Cytomegalovirus infection reduced the numbers of T cells, mainly manifesting the reduction of CD4 cells, which got worse with the progression of disease.