Study On The Changes In Serum C-Reactive Protein And Amyloid Protein Levels In Elderly Patients With Suspected Cognitive Impairment

Objective: To study the changes in serum C-reactive protein and plasma amyloid protein levels in suspected Alzheimer's disease (AD) patients. Patients and methods: Sixty patients that likely had AD according to preliminary diagnosis were selected as the observation group, while 60 healthy patients who did not have AD were selected as the control group. General patient characteristics, serum C-reactive protein (CRP), plasma amyloid beta A beta 1-40 and A beta 1-42 levels were observed in both groups. The 60 patients in the observation group were divided into a progressive group (n=13) and a non progressive group (n=47) according to disease progression. General patient characteristics, CRP, plasma A beta 1-40 and A beta 1-42 levels were compared between the two groups, and risk factors of disease progression were analyzed. Results: There were significant differences in serum CRP and A beta 1-42/A beta 1-40 between the two groups (all P<0.001). In terms of education level, mini-mental state examination (MMSE) score, A beta 1-42, A beta 1-40, and A beta 1-42/A beta 1-40, the non progressive group had higher levels than the progressive group, while the non progressive group had significantly lower CRP than the progressive group (P<0.05). Logistic regression analysis of the involved factors showed that two indicators, A beta 1-42/A beta 1-40 and CRP, could be considered risk factors for disease progression. Conclusion: Serum CRP levels were high and A beta 1-42/A beta 1-40 ratio was low in suspected AD patients and both could be used as risk factors for disease progression in suspected AD patients.