The Increase Of Serum Nse And Tbil Levels Related To The Severity Of Hibd

Objective: To investigate the significance of amplitude integrated electroencephalogram (aEEG), neuron-specific enolase (NSE) and total bilirubin (TBil) in the diagnosis and treatment of neonatal hypoxic-ischemic brain damage (HIBD). Method: Ninety infants with HIBD in our hospital were selected as the study subjects (group A), and 90 patients with normal full-term delivered in our hospital were selected as control group B. Group A was given hyperbaric oxygen therapy. The aEEG background activities of group A before and after treatment and group B were examined. The levels of NSE and TBil in the serum of group A before and after treatment and also in group B were detected by automatic biochemical analyzer. Spearman correlation coefficient was used to analyze the correlation between serum NSE and TBil levels and aEEG background activity. Results: The abnormal rate of background activity of group A aEEG was higher in Group A than that of group B (P<0.001). The levels of serum NSE and TBil in group A were higher than those in group B (P<0.001). The levels of serum NSE and TBil were positively correlated with background activity of aEEG (r=0.514, P<0.001; r=0.455, P<0.001). The effective rate of treatment for infants with normal aEEG background activity and mild abnormalities in group A was higher than that in infants with severe aEEG background activity (P<0.001). The treatment ineffectiveness of infants with a background activity of aEEG and mild hypoplasia was lower than that of infants with severe aEEG background activity (P<0.001). After treatment the serum levels of NSE and TBil were lower in group A than before treatment (P<0.001). Conclusion: The increase of serum NSE and TBil levels may be closely related to the severity of HIBD. Observation of aEEG background activity, serum NSE and TBil levels is of certain guiding significance for the treatment of HIBD in infants with hyperbaric oxygen.