Chelation, Characterization And Antibacterial Activities Of Some Mixed Isonicotinic Acid Hydrazide - Paracetamol Metal Drug Complexes

The structural properties of new Zn(II), Cu(II), and Cd(II) complexes bearing isonicotinic acid hydrazide and paracetamol ligands have been investigated. The newly synthesized compounds were characterized by various techniques such as FT-IR, elemental analysis, atomic absorption spectroscopy, conductivity measurement, magnetic susceptibility, and powdered x-ray diffraction. Based on the FT-IR of the new complexes, it was observed that the ligands act as bidentate donors. Other spectral and analysis confirms the synthesis of the compounds and their coordination with the ligand. The as-synthesized compounds were screened for potential antibacterial activity against some isolated organisms: Bacillus subtills, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Based on the results obtained, the assay revealed broad-spectrum antibacterial agents. The complexes were found to exhibit higher potency than the free parent ligands with no activities. According to powdered XRD data, Zn and Cd complexes were found to possess hexagonal crystal except for Cu, which is face centred cubic.