Effect Of Bifidobacterium Tetravaccine Tablets-Assisted Therapy On T Lymphocyte Subpopulation Of Children With Rotavirus Enteritis

This study aimed to explore the effect of bifidobacterium tetravaccine tablets-assisted therapy on T lymphocyte subpopulation of children with rotavirus enteritis. A total of 86 cases of children with rotavirus enteritis in our hospital were randomly divided into the control group and observation group. The control group were given conventional treatments, such as antiviral, fluid infusion, correction of fluid and electrolyte imbalance and acid-base imbalance, etc., while the observation group were given additional bifidobacterium tetravaccine tablets besides conventional treatments. Flow cell method (fcm) was adopted to analyze proportions of CD3+, CD4+ and CD8+ in peripheral blood lymphocyte subpopulations as well as CD4+/CD8+ ratio before and after treatment. Curative effect, antidiarrhea time, fever abatement time, extinction time of emesis and length of stay in the hospital (LOS) of two groups were compared. Compared to the control group, the observation group showed significantly higher proportions of CD3+ and CD4+ cells and CD4+/CD8+ ratio (P<0.05), but far lower proportion of CD8+ cells (P<0.05). The observation group achieved significantly higher overall response rate than the control group (P<0.05); antidiarrhea time, fever abatement time, dehydration correction time and LOS of the observation group were significantly shorter than those of the control group (P<0.05). In conclusion, the proposed bifidobacterium tetravaccine tablets-assisted therapy can prominently improve immuneal functions of children with rotavirus enteritis, clinical symptoms and curative effect and shorten curative time.