Analysis Of The Changes In Inflammatory Cytokines, Infection Factors And Coping Strategies After Intracranial Tumor Operation

Objective: This study aimed to investigate the changes in inflammatory cytokines and infection factors in patients with intracranial infection after intracranial tumor operation. Methods: Patients with meningioma admitted to our hospital from May 2015 to June 2018 were enrolled. Based on postoperative infection, the patients were divided into the infection group (n=309) and non-infection group (n=305). The levels of related inflammatory cytokines after operation were measured and the risk factors were determined by univariate analysis and multivariate logistic regression analysis. Results: Differences in the levels of serum C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were not obvious between the two groups of patients on the 1st day after operation (P>0.05). From the 3rd d after operation, the levels were remarkably higher than those in patients of the non-infection group, and differences in the levels of serum CRP, PCT, IL-6 and TNF-alpha between the two groups of patients became more obvious on the 7th and 14th d after operation (P<0.05). The multivariate Logistic regression analysis revealed that age, diabetes mellitus, operation time, posterior fossa operation and postoperative cerebrospinal fluid leakage were independent risk factors for patients with intracranial infection after intracranial tumor operation (P<0.05). Conclusion: Infection inflammatory cytokines, CRP, PCT, IL-6 and TNF-alpha, along with other infection factors, function as important indicators after Intracranial Tumor Operation, which provide new leads for the countermeasures of intracranial infection in clinical practice.