Correlation study on the blood pressure variability, serum high-sensitivity C-reactive protein and homocysteine of patients with stable angina pectoris and hypertension

To study the correlation among blood pressure variability, serum high sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) in patients combined with stable angina pectoris (SAP) and hypertension. A total of fifty-six patients with the isolated hypertension without any complications admitted to Wuhan No. 4 Hospital from June 2018 to June 2019 were included in the hypertension group, and at the meanwhile, 56 patients with SAP and hypertension admitted to Wuhan No. 4 Hospital during the same period were selected as complication group. The levels of Hcy and hs-CRP were detected and compared between the two groups of patients, and the blood pressure variability index was measured and calculated in the two groups of patients, in order to compare the types of blood pressure circadian rhythm in the two groups. The levels of serum hs-CRP and Hcy in the complication group were higher than those in the hypertension group, for which the difference was statistically significant (P<0.05). The normal rate of blood pressure circadian rhythm in the hypertension group was 62.50%, while it was 30.36% in the complication group. The circadian rhythm of blood pressure in the hypertension group was better than that in the complication group (P<0.05); the 24 h blood pressure level and blood pressure variability index of the complication group were higher than those of the hypertension group (P<0.05); the day variability indicators and night variability indicators of blood pressure in the complication group were higher than those in hypertension group (P<0.05); serum hs-CRP and Hcy levels were positively correlated with various blood pressure variability indicators (r=0.3, P<0.05). The incidence of reverse-dipper and deep-dipper blood pressure circadian rhythms was higher in SAP patients combined with hypertension, and the blood pressure variability was positively correlated with serum high-sensitivity C-reactive protein and homocysteine levels.