Synthesis, Characterization And Analgesic Activity Of Several New N-Substituted Phthalimide Analogues

The synthesis, characterization and spectroscopic studies of new N-substituted pthalimide analogues 2-7 with analgesic activity were described. The compounds were synthesized using phthalic anhydride with various appropriate amines (Triazolamine, Benzocaine, p-Nitro-aniline, pyrazinamide, Phenazone and glycine) in reflux synthesizer. The purity of the compounds was determined by TLC. With the physical and spectral data the structure of the new synthesized compounds were elucidated. The newly synthesized compounds were subjected for the screening of CNS activity by using standard experimental models. The analgesic activity of the selected compounds 27 were evaluated in vivo by ip carboxymethylcellulose (CMC) and acetic acid-induced 'writhing' test in mice. Compounds 2-7 were exhibited significant analgesic activity in hot-plate and acetic acid inducer screening test comparable to the control CMC (Carboxymethylcellulose) and aspirin.