Effect Of Clerodendrum Infortunatum On Testicular Tissue In Streptozotocine Induced Diabetes Rats

In diabetes, infertility is a common complication in diabetic men and experimental animals. The aim of this study was to investigate the protective effect of methanolic leaf extract of Clerodendrum infortunatum (MECI) on programmed cell death in the testicular damage resulting from streptozotocin (STZ) induced diabetes in rats. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg), and the rats were treated with MECI (250 mg/kg and 500 mg/kg) administered once a day orally for 28 days, starting 3 days after the STZ injection. Blood glucose were checked in diabetic induced animals. At the end of the study, all animals were sacrificed. Testis tissues were collected for the assessment of sperm parameters, and for biochemical and histopathological analysis. The MECItreated rats in the diabetic group showed an improved blood sugar, histological appearance, sperm parameters and program cell death. These results suggest that methanolic leaf extract of Clerodendrum infortunatum is a potentially beneficial in reducing testicular damage in diabetic rats.