Acceptability Of First And Second Trimester Screening For Fetal Down'S Syndrome - Interim Results From A Demonstration Trial

To study the acceptability of integrated first and second trimester screening for fetal Down's syndrome in a program which incorporates a choice between first trimester screening by nuchal translucency (NT) alone and integrated screening, 11292 women attending antenatal care before 20 weeks and wanting to have screening for fetal Down's syndrome are recruited. Among the 9088 (80.5%) who are under 15 weeks, 461 (5%) chose to have the first trimester NT only while 8627 (95%) chose to have IT. The overall false positive rate was 4% and the uptake of invasive test after positive screening was 75%. 12 cases of Down's syndrome was detected antenatally among the screened positive cases and 6 additional cases were detected because of structural abnormalities on ultrasound examination.