Expression Of Nerve Growth Factor Precursor, Mature Nerve Growth Factor And Their Receptors During Cerebral Ischemia-Reperfusion Injury
NEURAL REGENERATION RESEARCH(2011)
Abstract
We investigated nerve growth factor precursor (proNGF) and mature NGF expression in ischemic and non-ischemic cortices after cerebral ischemia-reperfusion injury. In both ischemic and non-ischemic cortices, proNGF was found to be present in the extracellular space and cytoplasm. In addition, mature NGF was expressed in extracellular space, but with a very low signal. In ischemic cortex only, proNGF was significantly decreased, reaching a minimal level at 1 day. Mature NGF was increased at 4 hours, then reached a minimal level at 3 days. The p75 neurotrophin receptor (p75(NTR)) was significantly decreased after ischemia, and increased at 3 days after ischemia. These results confirmed that proNGF was the predominant form of NGF during the pathological process of cerebral ischemia-reperfusion injury. In addition, our findings suggest that ischemic injury may influence the conversion of proNGF to mature NGF, and that proNGF/p75(NTR) may be involved in reperfusion injury.
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Key words
cerebral ischemia-reperfusion injury, nerve growth factor precursor, mature nerve growth factor, p75 neurotrophin receptor, cell apoptosis
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