Human Papillomavirus Infection And Its Risk Factors Among Women Receiving Health Check-Up In Changsha Area

Objective: To analyze the epidemiological features of human papilloma virus (HPV) among women who received health check-up in Changsha area. Methods: A total of 9,487 sexually active women were enrolled in this study. During the health check-up they received gynecological examinations, new PAT'S thinprep cytologic test (TCT), and detection of HPV DNA types. Meanwhile, the demographic data, sexual behavior-related information, and awareness of cervical lesions were collected using a self-designed questionnaire. Results: Of these 9,487 women, the overall HPV prevalence was 16.61%, which included the high-risk types (13.51%), low-risk types (0.67%), and intermediate-risk types (2.43%). HPV type 52 was most prevalent (20.43%). As shown by Logistic regression analysis, multiple sexual partners (n>3), frequent sexual activities (>3 times/week), and a family history of malignancy were the major risk factors of HPV infection. Half (50%) of the subjects were not aware that HPV infection is a high-risk factor for cervical cancer, and 44.6% did not know cervical cancer is preventable. Conclusion: The distribution of the HPV genotypes among the female health check-up populations in Changsha area is consistent with the distribution rules across China. Women with multiple sexual partners, frequent sexual activities, and/or a family history of malignancy are more susceptible to HPV infection.