Predictive Value Of Immunoscore In Patients With Colorectal Cancer

As increasing evidences suggest that tumor-infiltrating immune cells do influence tumor development. In this study, the expression of intratumoral neutrophils, CD3+ T cells and CD8+ T cells were assessed by immunohistochemistry from 207 specimens from patients with CRC following resection. Prognostic values for immunoscore were evaluated. The results showed decreased CD3+ T cells, CD8+ T cells, immunoscore, and increased neutrophils were all significantly associated with poor disease-free survival (DFS) and overall survival (OS) (P < 0.05). In multivariate analysis, immunoscore was not only an independent prognostic factor for DFS and OS, but also more advantageous over the use of current tumor staging (AJCC/UICC-TNM classification) for DFS (HR, 3.394; 95% CI, 2.209 to 5.213; P < 0.001 and HR, 1.275; 95% CI, 1.048 to 1.550; P = 0.015) and OS (HR, 3.904; 95% CI, 2.492 to 6.117; P < 0.001 and HR, 1.734; 95% CI, 1.423 to 2.114; P < 0.001). The receiver operating characteristic (ROC) curve analysis revealed the immunoscore to be the better predictor to TNM stages. Our data indicate that immunoscore is a strong independent prognostic factor, which may better predict the outcome for CRC patients.