The Effect of Single Anastomosis Duodenoileal Bypass + Sleeve Gastrectomy on Histopathological Findings and Metabolic Hormones in Obese Rats

Purpose: Single anastomosis duodenoileal bypass+sleeve gastrectomy (SADI-S) is one of the techniques with the effect of both restrictive and absorption reduction and a more up-to-date and safer modification of this highly effective surgery. In the SADI-S model performed on rats, we aim to identify mediators in obesity and stomach metabolism, histopathologic data, and the weight loss rate.Methods: Obese rats were divided into two groups, eight of them in the SADI-S group and eight in the control group. Both groups were measured for gastrin, ghrelin, and leptin levels before and 30 days after surgery and histopathologically examined.Results: In the SADI-S group, the decrease in blood ghrelin and leptin levels was statistically significant compared with the control group (p = 0.012 and p = 0.008). The blood gastrin level was found to increase significantly compared with the control group (p = 0.012). The decrease in levels of ghrelin and leptin, determined histopathologically, in the SADI-S group was statistically significant compared with the control group (p = 0.015 and p = 0.003). The increase in gastrin level was found to be statistically significant compared with the control group (p = 0.001). Histopathological examination revealed a statistically significant increase in foveolar hyperplasia (FH) and cystic glandular dilation (CGD) in the SADI-S group (p = 0.003 and p = 0).Conclusions: In our experimental model, SADI-S was found to be a more effective method for weight loss, compared with the control group, and development of CGD, which has the potential for coexistence with gastric cancer, was detected with FH.