Prevalence Of Distal Renal Tubular Acidosis In Patients With Calcium Phosphate Urolithiasis Using Furosemide Test
MEDICINA BALEAR(2017)
摘要
Introduction: Adults with distal renal acidosis (DRTA) commonly present urolithiasis and alkaline pH (>6). Calcium phosphate is the most common urolithiasis related with DRTA. The main objective of our study is to determine DRTA prevalence in patients with calcium phosphate lithiasis and alkaline pH (>6) using the furosemide test.Materials: We selected 40 patients, 17 men and 23 women, between 18 and 65 years old with calcium phosphate lithiasis and alkaline urine pH (>6) treated in our department. Age, sex, urolithiasis localization (unilateral or bilateral) and side effects by furosemide test were collected. We analysed sex and urolithiasis location with chi-squared test, age was analysed with T-test. We considered stadistical significance p<0'05. We performed the furosemide test for the DRTA diagnosis. It consists in the administration of 40 mg of furosemide orally. We performed a urine pH test before the furosemide administration to verify a urine pH higher than 6. In the following 3 hours after the furosemide administration we performed a urine pH test to each micturition. We considered a urine pH higher than 6 in all the urine tests diagnostic of DRTA.Results: 15 patients (37'5 %) were positive for DRTA with furosemide test (Figure 1). The mean age in DRTA group was 40,73 years, in the other group was 51,12 years, statistical significance was found (p<0'001) (Figure 2). All the patients (15) in the DRTA group presented with bilateral urolithiasis (p<0'001) (Figure 3). There were 10 women and 5 men in the DRTA group, no statistical significance was found (p<0'342). No side effects were reported with furosemide test.Conclusion: We conclude that the DRTA prevalence in our sample is 37'5% using furosemide test and the furosemide test is save. Our data suggest that bilateral urolithiasis and young age could be considered risk factors for DRTA.
更多查看译文
关键词
Distal renal acidosis, urolithiasis, furosemide, calcium phosphate
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要