Immunological Aspects Of The Use Of L-Carnitine In Sports Nutrition

The purpose of the work is to study the immunomodulating activity of L-carnitine in junior athletes during the training period Materials and methods. 20 junior athletes (masters of sports and candidates for masters of sports in swimming) aged 14-18 years participated in the study. Athletes were divided into 2 groups of 10 people each. Athletes of the main group received L-carnitine (600 mg per day) for 4 weeks in addition to the basic diet. Athletes of the control group received only basic diet without sports nutrition. Examination of athletes was performed at the beginning and after 4 weeks of the observation period Results. As a result of a comprehensive survey of junior athletes, the positive effect of L-carnitine intake on erythrocyte hemoglobin content (30.2 +/- 0.4 pg vs 28.3 +/- 0.3 pg at the beginning) was observed The relative content of basophilic leukocytes in athletes of the main group statistically significantly decreased by the end of the observation period - from 0.64 +/- 0.05% to 0.45 +/- 0.04%, which indicated an increase in the body's resistance to allergic reactions. The biomarkers of the immunotropic effect of L-carnitine are a decrease in the expression of the apoptotic marker CD95/Fas on peripheral blood lymphocytes and suppression of the production of pro-inflammatory cytokines synthesized by Thl lymphocytes with switching the response to humoral immunity. An evidence base for the effectiveness of the use of L-carnitine in sports nutrition for restoring immune dysfunction and adaptive potential of junior athletes has been provided.