Relationship Between Serum Crp, Bnp, Cypa, Il-1 Beta Levels And Prognosis Of Elderly Patients With Both Diastolic Heart Failure And Renal Insufficiency

The relationship between serum CRP, BNP, CyPA, IL-1 beta levels and prognosis in elderly patients diagnosed with both diastolic heart failure (DHF) and renal insufficiency (RI) was explored. A total of 76 patients with heart failure (HF) alone, 77 patients with RI alone, and 95 patients with both DHF and RI in our hospital were enrolled as Groups A, B, and C, respectively. The patients with both HF and RI were classified according to NYHA heart function. According to the glomerular filtration rate (EGFR), they were assigned to mild, moderate, and severe groups, and the correlation of CRP, BNP, CypA, and IL-1 beta with their prognosis was analyzed. Group C showed significantly higher levels of CRP, BNP, CyPA and IL-1 beta than other two groups (P < 0.05), and Group B showed significantly higher levels than Group A (P < 0.05). The levels of CRP, BNP, CyPA, and IL-1 beta in the serum of patients with both HF and RI increased with the increase of NYHA grade and the severity of RI (P < 0.05). A total of 39 patients with readmission or death within 6 months after discharge were classified into an incident group, 56 patients without readmission or death were classified into the non-incident group. The incident group showed significantly higher serum levels of CRP, BNP, CyPA and IL-1 beta than the non-incident group (P < 0.05). The logistic regression analysis revealed that age, CRP, BNP, CyPA, and IL-1 beta were independent risk factors for events in patients with HF and RI. Serum CRP, BNP, CyPA, and IL-1 beta are highly expressed in patients with both HF and RI; which can be adopted as a short-term prognosis indicators for patients with both DHF and RI.