Mss Score And Atrial Fibrillation Are The Risk Factors Of Intracranial Hemorrhage In Stroke Patients

Aim: Intracranial haemorrhage (ICH) is the main complication after intravenous thrombolysis. The aim of this study was to determine the predictive value of the Multicentre Stroke Survey (MSS) score combined with atrial fibrillation for ICH in stroke patients undergoing thrombolysis.Methods: A retrospective observational study was conducted with 287 participants from a single centre (67.2% males, median age 65 years). The participants' MSS scores were calculated based on four variables (age, glucose level, National Institute of Health Stroke Scale and platelet count on admission). Multivariate logistic regression was used to estimate the association between various risk factors and ICH. The predictive value of the MSS score alone and combined with atrial fibrillation was estimated by the area under the receiver operating characteristic curve (AUC), continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI).Results: A total of 41(143%) ICH events occurred. The MSS score was positively associated with atrial fibrillation on admission. Adjustment of ICH risk by atrial fibrillation improved the predictive value of the MSS score (increase in AUC from 0.74 to 0.80, P = 0.034; continuous NRI (>0) = 0.71, P<0.001; IDI = 0.06, P = 0.002).Conclusion: Atrial fibrillation on admission was positively associated with the MSS risk score, and their combination further improved the prediction of ICH risk for acute ischemic stroke patients undergoing thrombolysis.