Application of fast sensors to microscope mode spatial imaging mass spectrometry
JOURNAL OF INSTRUMENTATION(2011)
摘要
The application of fast detectors to microscope mode spatial imaging mass spectrometry, in which the two-dimensional distributions of particular ion masses over a sample are projected onto a two-dimensional detector, allows the imaging of all mass peaks desorbed from a sample on each time-of-flight cycle. Detecting all fragments per duty cycle means that fewer ionisation and acquisition cycles are required for a full set of data, leading to a reduction in overall detection time, amount of sample required, and sample degradation. Results from a proof-of-concept experiment, in which a fast frame transfer charge-coupled device camera (CCD) with 10 ns time resolution was coupled to a modified velocity-mapped imaging apparatus, are presented.
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关键词
Pixelated detectors and associated VLSI electronics,Instrumentation and methods for time-of-flight (TOF) spectroscopy,Mass spectrometers
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