Evaluation Of Highly Active Cytotoxic Agents In The Series Of Novel Derivatives Of N-Hydroxy(And N-Alkoxy)-Omega- (Benzeneselanyl Or 2-Benzoselenazolylsulfanyl)-Alkanamidines

Edgars Abele,Kira Rubina,Lena Golomba,Irina Shestakova,Elina Jaschenko,Veronika Bridane,Ramona Abele

HETEROCYCLIC LETTERS（2015）

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摘要

Synthesis of novel derivatives of N-hydroxy (and N-alkoxy)-omega-(benzeneselanyl)alkaneamidines and 2-benzoselenazolylsulfanyl)alkaneamidines as potential cytotoxic agents was carried out in two or three steps. 6-(Benzoselenazol-2-ylsulfanyl)-Nhydroxyhexanamidine exhibit high activity in vitro on monolayer tumor cell lines: MG-22A (mouse hepatoma) and HT-1080 (human fibrosarcoma).

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关键词

N-hydroxy (and N-alkoxy)-omega-(benzeneselanyl)alkaneamidines, N-hydroxy-omega-(2-benzoselenazolylsulfanyl)alkaneamidines, phase transfer catalysis, mouse hepatoma (MG-22A) cell line, human fibrosarcoma (HT-1080) cell line, cytotoxicity

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