Tgf-Beta 1-509c/T Polymorphism And The Risk Of Escc In A Chinese Han Population

Background: The studies investigating whether transforming growth factor (TGF)-beta 1-509C/T polymorphism is associated with the risk of ESCC is inconsistent. Methods: The TGF-beta 1-509C/T genotypes were determined by using a polymerase chain reaction (PCR)-restriction fragment length polymorphism assay and DNA sequencing analysis. The differences in demographic variables and genotype distributions of TGF-beta 1-509C/T polymorphism between ESCC patients and controls were calculated by Pearson's Chi square test. Associations between TGF-beta 1-509C/T polymorphism genotypes and ESCC risk were estimated by OR and their 95% CIs computed using unconditional logistic regression model. Results: There was a significant difference of TGF-beta 1-509C/T polymorphism genotype distribution between ESCC group and control group (P<0.001). With the CC genotype as reference, the adjusted OR for CT genotype reached to 0.78 (95% CI: 0.65-0.89; P=0.041), and the adjusted OR for TT homozygous carriers was 0.52 (95% CI: 0.33-0.78; P=0.017). The T allele carriage also presented a lower risk for ESCC (adjusted OR=0.43; 95% CI, 0.29-0.71; P=0.009). Conclusion: TGF-beta 1-509C/T polymorphism may contributes to ESCC susceptibility in Chinese population.