Cardioprotective Role Of Curcumin In Myocardial Ischemia-Reperfusion Of Male Albino Rats

Our present study investigates the antioxidant potential of curcumin against the myocardial ischemia-reperfusion (I/R) model of male albino rats. Reduction or alleviation of oxidative stress is a key factor to reduce ischemia-reperfusion based heart injury. Curcumin is well known natural agent and play a vital role in cardiac I/R damage. Myocardial I/R rat models were administrated curcumin utilized for in vivoinvestigation. H9C2 cell was used for the investigations. H9C2 cell viability, lipid peroxidation (MDA), superoxide dismutase (SOD) and catalase level was measured. Curcumin showed excellent antioxidant activity in the in vitro studies. Curcumin significantly inhibited oxidative stress-induced cell growth inhibitionand activated caspase 3 enzyme and bax/bax3 signaling pathways. Curcumin reduced significantly decreased apoptosis andsize of myocardial infarct in the I/R model of male albino rats. Taking all ou data together, it is concluded that curcumin is splendid antioxidant compound and significantly limits myocardial ischemia-reperfusion damage.