The Role Of Cytokines In The Course Of Acute Myocardial Infarction Complicated By Cardiogenic Shock

This study evaluates the plasma interleukin (IL) levels in a patient with acute myocardial infarction (AMI) complicated by fatal cardiogenic shock (CS).Remarkable changes were noticed in plasma tumor necrosis factor alpha (TNF alpha) level which reached two significant peaks. The first increase at 6 h after the onset of the symptoms was caused by AMI (80.11 pg/ml, vs. normal value 4.35pg/ml, SD 21.3 pg/ml). After a period of significant decrease, TNF alpha level was increasing until the end of observation because of CS (the last TNF alpha level was 204.1 pg/ml). Plasma IL 1 beta level was continually increasing. Plasma IL 6 reached the first peak, caused by AMI, nine hours after the onset of the symptoms (362.85 pg/ml, normal value < 10 pg/ml). Because of CS, after the short period of decrease, plasma IL 6 was increasing until the end of observation (the last IL 6 level was 859.61 pg/ml). Plasma IL 8 was also elevated throughout the time of observation.