Clinical Characteristics And Prognosis Of Collodion Babies

Objective: This study aimed to investigate the clinical characteristics of collodion babies. Methods: Clinical information of 16 collodion babies that received treatment in the Neonatal Intensive Care Unit, between 2009 and 2018, was retrospectively reviewed. Perinatal factors, clinical manifestations, therapeutic response, and findings from follow ups were analyzed. Results: There were 11 full-term babies and 5 premature babies. Caesarean section was noted in 13 cases (82%) and the first delivery in 12 (71%). Of these, the disease was cured in 16 cases and improved in 7 cases. One collodion baby refused to receive treatment and one died. Two babies developed skin sclerosis and decrustation, twice, due to concomitant pneumonia or sepsis. New skin slowly formed and complete formation of new skin was observed for up to 30 days in babies with sepsis. Infections (pneumonia and sepsis) often affect disease progression or cause recurrence, but they had no influence on prognosis. Prevention and infection control are crucial for treatment of collodion babies. Conclusion: Collodion babies usually have a good prognosis. Extra-hospital rational skin care is key for protection and maintenance of skin appearance and function and for improved quality of life.