Comparison Of Sedative Effects Between Dexmedetomidine And Propofol In Painless Artificial Abortion

Objective: The aim of this study was to compare the sedative effects of dexmedetomidine and propofol in painless artificial abortion patients, discuss the safety and comfort of the anesthesia method, and to provide relevant evidence for clinical anesthesia of painless abortion. Methods: Using the random number table method, this study selected 200 patients that underwent abortions in the Department of Anesthesiology of Jinhua Municipal Central Hospital, from January 2015 to December 2017. American Society of Anesthesiologists (ASA) grades Ito II were included, ages 18 to 40. A hundred cases of dexmedetomidine injections were used for induction and maintenance of anesthesia (Group D). A hundred cases of propofol injections were used for induction and maintenance of anesthesia (Group P). Heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO(2)), modified observer's assessment of alertness/sedation scale (MOAA/S), and incidence of respiratory depression, hypotension, sinus bradycardia, and other complications during surgery were compared between the two groups in T-0 (before anesthesia), T-1 (2 minutes after medication), T-2 (uterus dilatation), and T-3 (5 minutes after surgery), respectively. Results: There were no significant differences in MAP, HR, SpO(2) and MOAA/S scores between group D and group P at the time of T-0 (P>0.05). In group D, MAP and HR were lower than those in group P during T-1-T-3, but Spa, was significantly higher than that in group P (all P<0.0001). MOAA/S scores in group D were significantly lower than those in group P during T-1-T-3 (all P<0.0001). However, incidence of respiratory depression in group P was significantly higher than that of group D. Incidence of intraoperative hypotension and sinus bradycardia in group D were significantly higher than that of group P (all P<0.0001). Conclusion: In painless artificial abortions, the sedative effects of dexmedetomidine are significantly better than propofol and there is no respiratory depression. The hemodynamics of propofol are relatively more stable.