Downregulation Of Mir-138-5p Is Associated With Poor Prognosis In Human Bladder Cancer
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY(2017)
摘要
Accumulating evidence suggested that microRNA (miRNA) plays an important role in the carcinogenesis of bladder cancer. MicroRNA-138-5p (miR-138-5p) was dysregulated in human cancers including bladder cancer. However, its clinical significance remains unclear. We recruited 126 patients with bladder cancer in the study. Real-time quantitative polymerase chain reaction (RT-qPCR) was conducted for detection of miR-138-5p levels in tumor tissues and paired normal tissues. The prognostic significance of miR-138-5p in bladder cancer was further analyzed. MiR-138-5p levels were significantly decreased in the tumor tissues compared with the non-cancerous tissues. In addition, low levels of miR-138-5p were strongly associated with various clinicopathological parameters including TNM stage and histological grade as well as Ki-67 staining intensity. Bladder cancer patients with lower miR-138-5p levels had worse 5 year overall survival and recurrence free survival rates. Finally, multivariate analysis demonstrated that miR-138-5p was an independent prognostic factor for bladder cancer. Overall, our study indicated that miR-138-5p might serve as a useful prognostic biomarker for patients with bladder cancer.
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关键词
Bladder cancer, miR-138-5p, prognosis
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