Advances In Pharmacogenomic Studies Of Docetaxel-A Review

Docetaxel is currently utilized in the treatment of breast cancer, non-small cell lung cancer, prostate, and a variety of other cancers. However, there exists a significant difference in individual drug sensitivity and toxicity. In this paper, we review the genetic variation of drug metabolism related genes, correlations between the genetic polymorphisms of CYP450, ABC, SLCO1B3, and GSTs, as well as the clinical efficacy and adverse drug reactions of docetaxel, in order to provide a theoretical basis for an individualized approach to medical management.