Effects Of 1,25-Dihydroxyvitamin D-3 On Islet A Cell And Beta Cell In Multiple Low Dose Streptozotocin-Induced Diabetes Rats

To study the prophylactic effects of 1,25-dihydroxyvitamin D-3 on a cell and beta cell of pancreatic islet of diabetes rats induced by streptozotocin. Streptozotocin-induced diabetes rats were orally administrated with 1,25-dihydroxyvitamin D-3 every day for 4 weeks. The incidence and Glucose AUC of diabetes in the 1,25-dihydroxyvitamin D-3 group was much less than in STZ group, while insulin AUC in the 1,25-dihydroxyvitamin D-3 group was larger than that in the STZ group. TNF alpha and BAX expression in 1,25-dihydroxyvitamin D-3 group were declined in comparison with those in STZ group. Therefore, 1,25-dihydroxyvitamin D-3 may prevent Sprague-Dawley rat from diabetes induced by streptozotocin probably through downregulating the expression TNFa and BAX, which may lead to enhance the islet apoptosis and hyperglycemia.