Brain Biomarkers For The Development Of Motor Injury In Term Newborns Exposed To Chorioamnionitis

L. Katikaneni, D. Mulvihill,C. B. Johnson, J. Perkel, D. Lambert,D. Jenkins

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE（2012）

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Abstract

6-dependent activation of JAK/STAT3 signaling in specific subsets of neurons. Furthermore, MIA leads to changes in global transcriptional profiles in the brain, over 90% of which are abrogated in brains of offspring from poly(I:C)-injected IL-6 knockout mothers. These results support a key role for IL-6 in the placenta and fetal brain in shaping neural development and behavior in the MIA offspring.

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