One-Pot Synthesis Of A New Generation Of Hybrid Bisphosphonate Polyoxometalate Gold Nanoparticles As Antibiofilm Agents

A reduced polyoxovanadate functionalized with bisphosphonate molecules was synthesized and used to prepare in one step hybrid organic-inorganic polyoxometalate decorated gold nanoparticles. These new composites were shown to strongly inhibit P. aeruginosa and S. epidermidis biofilm growth, with the three components constituting the nanoparticles (Au-0 core, vanadium and alendronate) acting synergistically.