The Effect Of Akt Substrate On Exercise Promoting Glucose Transport

Some data from epidemiological research suggest that individuals with obesity, type 2 diabetes(DMT2) display a variety of degree of insulin resistance (IR) Accumulating evidences also reveal that increased dysfunction in some signal pathways involving in glucose and lipid metabolism and cardial vascular component is frequently considered to be the major cause of IR, and as a potential therapeutic target to some disease it has caused great concern Thus the ways to enhance sensitivity to insulin and glucose uptake has become urgent issues to be solved There is irrefutable evidence that exercise training is an effective therapeutic intervention to increase insulin action in skeletal muscle via insulin-independent mechanism that bypasses the insulin signalling defects associated with IR and DMT2 conditions, however the underlying regulation remains unclear Moreover, recent studies indicate that AS160, a Rabase-binding protein, which is a downstream substrate of Akt, plays an important role m mediating GLUT4 trafficking during Insulin-PI3K Akt/AS160 signal Of particular interest, besides insulin signal, the role of AS 160 activation involving in GLUT4 trafficking is increased by many stimuli Here we review the effect of AS 160 on training improving the glucose transport considering its potential role in GLUT4 trafficking, aiming to provide some theoretic evidence for prevention and treatment of IR and relative metabolic abnormalities through activity since it is impaired in some individuals with obesity or DMT2