Influence Of Different Anesthesia Methods On The Cognitive Ability And Myocardial Damage In Cardiac Surgery

Objective: Cardiac surgery is associated with some degree of cognitive dysfunction and myocardial injury. The aim of this study was to investigate the effect of two anesthesia methods on cognitive ability and myocardial damage in cardiac surgery patients. Methods: 90 patients undergoing cardiac surgery were collected in the study and were randomly divided into sevoflurane (S) and propofol (P) group. MMSE was performed to measure the cognitive function of patients. Heart rate (HR), mean arterial pressure (MAP), cardiac index (CI), and cardiac function index (CFI) were monitored and cardiac troponin I (cTnI), myoglobin, and creatinine kinase MB isoenzyme (CKMB) were determined using sandwich enzyme immunoassay method. Results: Compared to T0 time, the MMSE score was significantly decreased at T2 and T3 in both S and P groups, but no significant difference was found between the two groups. Moreover, there were no differences for any of the haemodynamic variables between the two groups, except CI at T4 time. And the concentration of cTnI, myoglobin, and CKMB increased significantly post-operatively with a peak at T2 time point in S and P groups. The level of cTnI and CKMB was lower in S group than in P group at T2. Conclusions: No significant difference was found on the influence of two anesthesia method on post-operative cognitive function. The implementation of seveflurane anesthesia in cardiac surgery may exhibit a more favorable cardioprotective function and promote patients recovery.