Self Emulsifying Delivery System -Mostly Discussed But Still Remained Challenging Aspect To Enhance The Oral Absorption Of Lipophilic Drug

Oral route of drug delivery is the simplest and most accepted way of administration of drugs due to greater stability, high patient compliance, accurate dosage, cost effectiveness and high patient compliance of drugs. But with oral formulations bioavailability is the major problem for newly discovered drug because 40 percent are lipophilic compounds. There are several factors responsible for low oral absorption of hydrophobic drugs and one very particular one is poor absorption due to slow and/or incomplete drug dissolution and precipitation in the gastro-intestinal lumen or other aqueous media. Therefore in order to be delivered orally and to achieve acceptable bioavailability, lipophilic drugs require a co-administered drug delivery system. This article mainly gives overview of technologies available with special emphasis on mechanism of SEDDS and potential for commercialization of formulation as compared to other technologies along with examples. But there are certain disadvantages of SEDDS like lack of good predicative in vitro models for assessment of the formulations and higher concentrations of surfactant used may cause some allergic reactions. So it requires more development and still remained challenging aspect to enhance oral absorption of lipophilic drugs.