New-Onset Diabetes In Kidney Transplant Recipients: Risk Factors, Impact On Allograft Failure And Mortality

lntroduction:New onset diabetes after transplantation (NODA T) is a serious, yet common complication following kidney transplantation, associated with an increased risk of allograft failure, cardiovascular complications, death and important healthcare costs.Material and methods: We performed a retrospective, observational study on 219 adult non-diabetic kidney recipients, who underwent transplantation between 2007 and 2010, over a 3 years follow-up period. The main end-points of our study were to evaluate the risk factors associated with NODA T development and the incidence and impact of NODAT on allograft failure and mortality. Among 219 patients, 8.2% developed NODA T during the 3 years follow-up period. By mutivariate logistic regression, use of cyclosprine with mycophenolate mofeti/regimen (OR 3.4, Cl 95% 1. 02-11.88, p= 0. 04) and pre-transplant infection with hepatitis C virus (OR 5.79, Cl 95% 1.32-25.42, p= 0.02) were independent risk factors for NODAT. NODA T was not a risk factor for allograft failure and mortality. BK virus infection (HR 6.94, Cl 95% 1.27-37.93, p= 0.02) and the presence of proteinuria > 300mgl24h at 2 years after transplantation (HR 16.37, Cl 95% 3.32-80.73, p= 0.001) have been associated with kidney graft failure.ConcluThe use of cyclosporine with mycophenolate mofetil regimen and pretransplant infection with hepatitis C virus were independent risk factors for NODA T development. NODA T was not associated with allograft failure and mortality in our study.