Transcriptome Analysis Identified Feature Genes And Enriched Gene Functions Relating To Psoriasis

Psoriasis is an inflammatory chronic disorder mediated by cells of immune systems. To know more about the pathogenesis underlying differentially expressed genes (DEGs) of psoriasis, we used all the 64102 annotated genes to assay the transcriptome of psoriatic and normal skin based upon public available RNA-Seq data. We identified 2906 DEGs (p.adj<0.05), of which 1365 were down-regulated and 1541 were up-regulated in psoriasis. Transcription-factor binding sites (TFBS) of NFKBRELA, IRF1, STAT1 showed significantly enriched among the up-regulated DEGs. We also confirmed that cytokines in immune system play an important role in psoriasis.